Everton Under-21s' Papa John’s Trophy last-32 clash with Mansfield Town will take place on Wednesday 30 November (7pm GMT) at Goodison Park.
Paul Tait's side have been in impressive form this campaign and reached this stage of the competition by topping Northern Group A, with victories over Harrogate Town and Hartlepool United from their opening three matches.
The young Blues now face Nigel Clough's Mansfield Town, who currently sit in the play-off places in League Two after 18 games.
Tickets for the Goodison Park clash will be announced on evertonfc.com in due course.
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HIGHLIGHTS: HARTLEPOOL 0-6 EVERTON U21s