James Tarkowski and Dwight McNeil will make their official Everton debuts in the Blues' opening fixture of the 2022/23 Premier League season against Chelsea at Goodison Park (5.30pm BST).
Fellow summer signing Ruben Vinagre is named among the substitutes.
Jordan Pickford starts in goal for the Toffees, shielded by three centre-backs in Tarkowski, Yerry Mina and Ben Godfrey, while Nathan Patterson and Vitalii Mykolenko will be deployed as wing-backs.
Alex Iwobi and Abdoulaye Doucoure start in midfield, following on from impressive displays in the 3-0 home win over Dynamo Kyiv in Everton's final pre-season match last weekend.
Manager Frank Lampard, who is without Dominic Calvert-Lewin (knee) and Salomon Rondon (suspended), names an attacking trio of McNeil, Demarai Gray and Anthony Gordon from the start.
New for 2022/23, Premier League clubs are permitted to make five substitutions each game during three windows during a match, plus at half-time.
A total of nine substitutes can be named on the teamsheet.
As well as Vinagre, Asmir Begovic, Mason Holgate, Michael Keane, Allan, Dele, Jean-Philippe Gbamin, Lewis Warrington and Stanley Mills are also named on Everton's bench for the opening-day clash with Thomas Tuchel's side.