Everton manager Frank Lampard has revealed Yerry Mina is fit and available for Saturday's 2022/23 Premier League curtain-raiser on Saturday (5.30pm BST).
But the Blues will host Thomas Tuchel's side at Goodison Park without Dominic Calvert-Lewin, who is facing "around six weeks" on the sidelines after suffering a knee injury in training this week.
Speaking in his pre-match press conference, boss Lampard revealed the knock is not related to any previous injuries.
He said: "Losing a player like Dominic, with his quality, in the week going into the first game is obviously going to affect you.
"I think we're probably looking at around six weeks for the injury. I saw a lot of crazy rumours yesterday, but he's been assessed over a couple of days and that's where we're at.
"It comes with the territory of having a squad and training at this level. We'll have to work around it. Other players will have to step up and do the job and hopefully that six weeks passes relatively quickly and we get Dominic back.
"No [it's not related to previous injuries]. Dominic was looking great - really fit, really strong. I've taken him out of one pre-season game as a precaution but through pre-season we were constantly commenting on how good he looks. It was very positive. So, it's a knock for everybody, particularly for him because I know the feeling as a player when you're getting pumped up and ready for a new season.
"I feel for him but we'll support him, as we always do, then as a team and a squad we have to look at the games in front of us."
With fellow striker Salomon Rondon also set to miss out as he serves the final game of a three-match ban after being sent off against Brentford back in May, Lampard admitted the Blues will look to strengthen their attack in the closing weeks of the transfer window.
"I wouldn't speak about individual targets, but I think in the area of the pitch, yes," he continued. "We are obviously aware of what we have.
"We lost Richarlison, who was versatile across the front as well. I know we've brought in Dwight McNeil, but we're very aware of the areas we want to strengthen.
"Going into the first game with Salomon suspended as well makes it pretty clear that I think that might be one of the areas we look at."
Allan and Asmir Begovic could be part of the matchday squad after overcoming injuries, but Lampard called for caution as the pair regain match fitness.
Seamus Coleman is also closing in on a return to action, with the captain set to take part in an Under-21s match against Blackburn Rovers on Friday night.
Tom Davies is expected to resume training next week, while André Gomes remains "a week or two away" from returning and Andros Townsend remains a long-term absentee after suffering an ACL injury in March.
