Rafa Benitez says he expects Richarlison, Jordan Pickford and Seamus Coleman to be out for around two to three weeks after the trio missed Saturday's 3-0 defeat at Aston Villa through injury.
The Everton manager also revealed Jean-Philippe Gbamin was unavailable for the clash at Villa Park as a precaution after feeling discomfort in his quadriceps.
Richarlison sustained a knee injury in the 3-1 victory over Burnley at Goodison on Monday night, while Pickford suffered a shoulder problem in the same game.
Coleman, meanwhile, picked up a hamstring strain during training at USM Finch Farm on Friday.
Benitez told evertontv: "At the moment we think it would be two to three weeks minimum [for Richarlison, Pickford and Coleman] and after we will see.
“[Gbamin] was a little bit tight in his quadriceps so as a precaution we decided to keep him out of the squad.”