Everton will open their Under-18 Premier League North season with a trip to Leeds United on Saturday 14 August.
Manager Paul Tait’s team play their first home game seven days later, on Saturday 21 August, when champions Manchester City visit USM Finch Farm.
The campaign’s first Under-18 Merseyside derby is set for 30 October, with the return at Everton’s Finch Farm training headquarters scheduled for 26 February.
Everton wrap up their 2021 fixtures away against Derby County on 18 December.
The season restarts three weeks later, on 8 January, when Everton – most recently champions at this level in 2013/14 – host Stoke City.
Premier League North features 14 teams, who face each other home and away, with the winners playing-off against the top side in the southern equivalent for the right to be called national champions.
Everton complete their regulation season at Blackburn Rovers on 7 May.
The meeting with Leeds at the Yorkshire club’s Thorp Arch training ground next month kicks off at midday.