Everton duo Richarlison and Yerry Mina both started for their countries as Brazil and Colombia boosted their chances of qualification for next year's World Cup finals in Qatar.
Mina played the full match as Colombia came back from two goals down against Argentina to draw 2-2 in Barranquilla.
The hosts were left with a mountain to climb when Argentina stormed into a two-goal lead with just eight minutes on the clock after strikes from Cristian Romero and Leandro Paredes.
But Luis Muriel's penalty six minutes after half-time gave Colombia hope - and they secured a vital point four minutes into injury-time courtesy of Miguel Borja.
The draw puts Colombia into fifth place in the 10-team South American qualifying group, level on points with Uruguay in fourth and one behind Ecuador.
The top four nations automatically qualify for the World Cup finals, with the fifth-placed team going into an inter-confederation play-off.
Brazil currently sit top of the table with a perfect start of six wins from six matches following their 2-0 triumph over Paraguay in Asunción.
Richarlison featured for 82 minutes and played a part in Neymar's early opener before Lucas Paqueta secured the points in injury-time.
The Selecao took the lead with four minutes on the clock when Gabriel Jesus wriggled free down the right flank and sent a cross into the area for Richarlison. The Everton forward couldn't get clean contact under pressure from Robert Rojas but it was enough to allow Neymar to slot home.
Richarlison, who netted in Brazil's 2-0 win over Ecuador on Saturday, thought he had another international goal on the stroke of half-time as he was sent clear and showed silky skill to finish past keeper Antony Silva, only to see the offside flag raised.
Brazil now sit six points clear of rivals Argentina in the South American World Cup table and return to qualifying action on 2 September when they travel to seventh-placed Chile, while Colombia go to Bolivia on the same day.