Carlo Ancelotti says Jordan Pickford, Allan, Andre Gomes and Joshua King will be fit to face Tottenham Hotspur at Goodison Park on Friday night (8pm BST) but Dominic Calvert-Lewin will miss the game.
Ancelotti added he expects Calvert-Lewin to be ready to return in the Blues’ match at Arsenal on Friday 23 February, with Yerry Mina, Fabian Delph and Bernard also in contention for the Emirates Stadium clash.
Abdoulaye Doucoure remains out with a foot injury.
The Everton boss confirmed Jean-Philippe Gbamin will not be available for the remainder of the season.
It was revealed on Wednesday that the midfielder will not require surgery on the medial collateral ligament knee contact injury he sustained during training last weekend.
Speaking at his pre-match press conference, Ancelotti said: “Available for the game are Jordan Pickford, Allan, Joshua King and Andre Gomes.
“In the next week we are going to have Dominic Calvert-Lewin, Yerry Mina, Fabian Delph and Bernard.
“It will be longer for Gbamin and Doucoure.
“Gbamin doesn’t need surgery but he will be out for at least eight weeks. The plan for him is to be back for the start of the new season.”
The number of injury absentees in the Everton squad meant the Blues started Monday’s game at Brighton with five players among the substitutes who had before never played in a Premier League match.
Ancelotti says the availability of Pickford, Allan, Gomes and King will provide a significant boost for Friday’s clash with seventh-place Spurs – adding the quartet are “in good condition”.
Victory at Goodison would see Everton leapfrog Tottenham in the Premier League and move to within three points of Chelsea, who currently occupy fifth position in the table.
“It is true we have had a lot of injuries and we are in a difficult moment to manage this,” Ancelotti added.
"During the season, we were able to manage the absences of Allan, Lucas Digne, Richarlison and James at times.
“But to have a lot of injuries all the same time is more difficult.
“But, while we still have some players out, I think the squad is better for tomorrow [than for the Brighton game] and I think we can compete against Tottenham.
“The fitness of the team in general is good. Against Brighton, physically we were good.
“Also, the players that come back after injury are good condition. They don’t need minutes to play to be fit – they are already fit.”