Carlo Ancelotti has revealed James Rodriguez will miss Everton's Premier League game against Newcastle United at St James' Park on Sunday (2pm BST) with a "small problem".
Ancelotti says he expects the Colombian to be available for next Saturday's home clash with Manchester United.
Jonjoe Kenny and Jarrad Branthwaite are available for selection again after recovering from ankle problems.
Club captain Seamus Coleman remains sidelined with a hamstring injury, however, while Mason Holgate (toe) is also unavailable.
Striker Cenk Tosun (ACL) and midfielder Jean-Philippe Gbamin (Achilles) are both continuing their rehabilitation programmes.
Richarlison and Lucas Digne miss out through suspension.
"James has played all the games and has a little problem," said Ancelotti, who was speaking at his pre-match press conference.
"He needs to rest in this game and I think he will be available for the next game.
"The fact we have players out, it is important to recognise the quality of the squad.
"Other players will get the chance to play, to show their quality and help the team to stay at the top [of the table]."