Andre Gomes is included in Portgual's party for next month's Nations League clashes with Croatia and Sweden, while Republic of Ireland boss Stephen Kenny's first squad features Everton captain Seamus Coleman.
Everton midfielder Gomes earned a recall from manager Fernando Santos last year but was an unused substitute for games against Luxembourg and Ukraine.
He missed out on his country's next get-together after sustaining the ankle injury which severely disrupted the 27-year-old's 2019/20 campaign.
Gomes, who won the most recent of his 29 caps in March 2018, returned from his layoff to play 11 games for Everton before the end of last term.
Defending champions Portugal begin their Nations League campaign against Croatia in Porto on Saturday 5 September.
Santos, who masterminded Portugal's 2016 European Championship success, takes his team to Stockholm for the meeting with Sweden three days later on Tuesday 8 September.
Republic of Ireland, meanwhile, begin the Nations League with a trip to Bulgaria on 3 September and three days later welcome Finland to Dublin's Aviva Stadium.
Kenny has replaced Mick McCarthy at the helm and is poised to retain Coleman as his country's skipper, with the full-back aiming to add to the 56 senior caps he has gained since a debut nearly 10 years ago.