Everton caretaker manager Duncan Ferguson has revealed Theo Walcott and Morgan Schneiderlin will miss Sunday's match at Manchester United (2pm).
Both players have suffered calf injuries, with Walcott expected to be out for three weeks and Schneiderlin for a fortnight.
Ferguson added Seamus Coleman, Yerry Mina and Fabian Delph have resumed light training over the past three days. Their fitness will be assessed ahead of the trip to Old Trafford.
The caretaker boss added he is "hopeful" Lucas Digne will be fit after the Frenchman took part in training on Friday.
Jean-Philippe Gbamin (quadriceps) and Andre Gomes (ankle) continue to be long-term absentees.
Asked about missing Schneiderlin and Walcott for Sunday's contest, Ferguson said: "It’s very disappointing, considering how well they played [against Chelsea] – Theo on the counter-attack and Morgan covering the space in front of the back four.
"It’s a blow but we move on."
Club captain Coleman has been sidelined with a rib injury in recent weeks, having last featured in Everton’s clash with Norwich City on 23 November.
Mina missed last weekend’s 3-1 win over Chelsea with a hamstring injury, while Digne picked up a groin injury in that game.
Delph has been out of action for a number of weeks with a muscle problem.