Everton Under-23s tackle newly-promoted Southampton in a Premier League 2 contest at Southport's Pure Stadium on Friday (7pm).
David Unsworth's side beat League Two Mansfield Town on penalties earlier this week, an outcome which the manager viewed as just reward for his players' "best" performance of the campaign.
Anthony Gordon was on target in that Leasing.com Trophy game, which ended 1-1 after normal time – the striker adding to his double in a 2-2 Premier League 2 draw at Arsenal seven days ago.
Indeed, Everton have started the defence of their Premier League 2 crown with a trio of draws.
They finished scoreless with Wolverhampton Wanderers a fortnight ago after opening the season with a similar result at home against Leicester City.
Southampton were pipped to last season's Division 2 title by Wolves, who claimed the automatic promotion spot on goal difference.
The South Coast side nevertheless won play-off ties against Aston Villa and Newcastle United to book their Division 1 berth. They come to Everton following successive defeats by Derby County and Liverpool but opened the season with a 4-3 success at Manchester City.
Season Ticket and Lounge Members, as well as fans who who have signed up to the Club's Official Membership scheme, can attend Friday's match FOR FREE.
Free entry to Under-23s and Everton Ladies matches is one of several perks which Official Members receive. Click here for a full list of benefits or to sign up as an Official Member.
Prices on the gate for non-Season Ticket, Lounge and Official Members are £5 for adults and £3 concessions.