Moise Kean will make his full Everton debut in Wednesday night's Carabao Cup tie with Lincoln City.
There are also first Blues starts for Fabian Delph, Alex Iwobi and Djibril Sidibe, as Marco Silva makes five changes from Friday's Premier League game at Aston Villa.
Mason Holgate comes in at centre-half alongside Michael Keane, with Lucas Digne stationed on the left of defence and French compatriot Sidibe on the right.
Another Frenchman in Morgan Schneiderlin partners Delph in the centre of midfield.
Gylfi Sigurdsson captains Everton from a position behind Italy international striker Kean, while Iwobi and Richarlison will operate on the flanks.
Silva's bench features a trio of attacking options in Dominic Calvert-Lewin, Cenk Tosun and Theo Walcott.
The manager's complement of substitutes is completed by Andre Gomes, Yerry Mina, Leighton Baines and goalkeeper Maarten Stekelenburg.