Everton goalkeeper Jordan Pickford won his 11th England cap as the Three Lions were edged out 2-1 by Spain in their Nations League opener at Wembley.
The 24-year-old stopper produced a typically confident, assured performance in his first international game following his World Cup heroics but - after Marcus Rashford put England ahead - goals from Saul Niguez and Thiago Alcantara saw Luis Enrique’s team run out winners in the Group A4 clash.
Gareth Southgate's men went in front after 11 minutes, Manchester United striker Rashford sweeping home after an excellent ball from club teammate Luke Shaw.
Spain’s response was immediate, however, Atletico Madrid midfielder Saul firing low into the bottom corner from eight yards out.
And the turnaround was complete just after the half-hour mark when Valencia forward Rodrigo stabbed home from Thiago’s free-kick delivery.
The Three Lions pressed for an equaliser in the second half and thought they struck in stoppage time. Danny Welbeck had the ball in the net - finishing from close range after David de Gea fumbled - but the referee chalked the goal off, ruling the Arsenal man had a committed a foul.
Next up for Pickford and England is a friendly with Switzerland at the King Power Stadium on Tuesday night.
The Swiss will head into the game in buoyant mood after a 6-0 victory over Iceland in their Nations League game in St Gallen.
Everton playmaker Gylfi Sigurdsson captained Iceland on his 29th birthday but the home side proved too strong in the Group A2 opener.
Steven Zuber and Dennis Zarkaria gave Switzerland a 2-0 lead at half-time, before Xherdan Shaqiri, Haris Seferovic, Albian Ajeti and Admir Mehmedi netted after the break.
Sigurdsson’s Iceland are in Nations League action again on Tuesday night and will look to hit back when they take on Belgium in Reykjavik.