Sandro Ramirez and Davy Klaassen are named in the starting line-up as David Unsworth makes nine changes to his team for the Europa League clash with Atalanta.
Joel Robles makes his first competitive appearance of the campaign, with Jordan Pickford named on the substitutes’ bench.
Michael Keane and Jonjoe Kenny are the only two players to retain their starting berths from the side Unsworth started with for the 2-2 draw against Crystal Palace last weekend, while Ashley Williams and Cuco Martina complete the back four.
Klaassen, Beni Baningime and Tom Davies make up a midfield trio, with Wayne Rooney, who will wear the captain’s armband, Kevin Mirallas and Sandro Ramirez in attack.
On the bench, Pickford is joined by Academy product Morgan Feeney, Idrissa Gana Gueye, Muhamed Besic, Nikola Vlasic, Ademola Lookman and Dominic Calvert-Lewin.