Nikola Vlasic will make his first Everton start in Atalanta as Ronald Koeman makes a raft of changes to his team for the Europa League group stage encounter following the weekend defeat by Spurs.
Goalkeeper Maarten Stekelenburg plays for the first time since the Europa League third qualifying round first-leg game with MFK Ruzomberok, with captain Phil Jagielka returning to the heart of defence in place of Ashley Williams.
Mason Holgate is set to be deployed at right-back, with Jagielka joined in the middle of the back four by Michael Keane and Leighton Baines retaining his spot at left-back.
Dominic Calvert-Lewin will make his first start since the Premier League draw with Manchester City and looks likely to spearhead the Blues’ attack.
Muhamed Besic comes into the team to partner Morgan Schneiderlin in Everton’s engine room.
That pair will hold in midfield behind the trio of Vlasic, Gylfi Sigurdsson and Wayne Rooney.
Regular number one Jordan Pickford is on the bench, joined by Williams, Sandro Ramirez, Cuco Martina, Tom Davies, Idrissa Gueye and Davy Klaassen for company.