Ronald Koeman has said both Morgan Schneiderlin and Aaron Lennon will not be involved again against Manchester United.
The pair sat out the defeat at Liverpool and the Blues boss revealed they are set to miss out again at Old Trafford.
However, he did confirm Schneiderlin is progressing well from the calf injury he sustained in the 4-0 win over Hull City and is in line to face Leicester at Goodison on Sunday.
“We will have the same players available as last weekend,” said Koeman. “Morgan is doing really well. I think he can be available for the weekend, but not for tomorrow.
“It is the same for Lennon. He is not in a physical way to be part of the team tomorrow.”
It is a tight turnaround for Everton who have little time to recover before they lock horns with their North West rivals. But Koeman insists his side will be ready.
"It’s difficult and maybe now more difficult because of the injuries we’ve had in the last week or so. In three or four days, we’ve not really had a long time to recover but for Manchester United its the same. We don’t need to travel far, which is good, and we’ll train to be prepared for the game."
The Blues boss also confirmed there is no update on James McCarthy, while he will also again be without long-term absentees Seamus Coleman, Yannick Bolasie and Ramiro Funes Mori.
Koeman has said he will be heading to Ireland next week to visit Coleman, who is recovering from surgery on a broken leg.
“He is at home, and day by day his mood will be better,” he added. “Next week I will go to see Seamus.”
Koeman insisted that he will continue to hand first-team opportunities to the younger players in his squad.
There were six members of his matchday squad aged 22 or younger for the Merseyside derby, and the Toffees manager told reporters they will retain their places in the group.
“The best way to get experience is to play,” he continued. “I am a manager who, if young players are developing and we have some problems with injuries like we have, then I will give them opportunities. That’s the future of the club.
“Everyone is always talking about the Academy at Everton. I am the right manager for that, I will give them opportunities because I am Dutch and not afraid to do so.”