Everton Under-21s face Aston Villa at Goodison Park on Monday evening.
With the first-team in action at West Brom, the Blues' second-string will simultaneously compete in their return to league football.
Alan Stubbs' side last played competitively against Wolves in the Premier League Cup on 20 December.
And with the majority of the Under-21 regulars out on loan, the Blues are expected to field a very youthful side.
Admission is free for Season Ticket holders and FOREVERTON members - £5 for adults and £3 for concessions otherwise.
Supporters unable to attend can follow match updates via Twitter here.