Gerard Deulofeu starts for Everton for the first time against Valencia.
The Spanish teenager, on loan from Barcelona, has so far only had a brief cameo against Real Madrid.
Joel Robles also gets his first start of the USA tour in goal.
Juventus penalty hero John Stones is back in the side, along with Bryan Oviedo in the opposite full-back position.
A youthful Blues side also includes Ross Barkley in midfield with Victor Anichebe returning to start up front.
Everton: Robles, Gibson, Jagielka, Oviedo, Deulofeu, Naismith, Distin , Barkley, Fellaini, Stones, Anichebe.