Kevin Mirallas is out of Saturday's trip to Reading, manager David Moyes has confirmed.
The Belgian limped off during last week's 2-1 win over Sunderland after suffering a hamstring strain and will not travel to the Madejski Stadium.
Meanwhile, Moyes will also be without Darron Gibson for a 10th successive game as the Irishman is yet to recover from his thigh tendon problem.
"He [Mirallas] won't be fit for this game and I'm not quite sure how long he'll be out for," said Moyes. "It's not as bad as we thought but he will not be fit for this game. Darron is still injured [as well]."
Moyes also has a number of other doubts but will assess the fitness of his squad on Friday.
Victor Anichebe (hamstring) and Tony Hibbert (calf) both missed the victory over the Black Cats last weekend, the latter having not featured since September's 2-2 draw with Newcastle.
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