Everton's Youth Cup game against Southampton will take place on 10 December.
The third round clash sees the young Blues head to St Mary's Stadium for a 7pm kick-off.
The draw was made last week and sees the Toffees, winners in 1998 and runners-up in 2002, face the Saints, who were runners-up in 2005.
Both clubs boast impressive academy alumni including the likes of Wayne Rooney, Leon Osman, Tony Hibbert, Theo Walcott and Gareth Bale.
evertonfc.com will have live text coverage from St Mary's with evertontv delivering highlights of the game.