Leon Osman could become Everton's latest international on Wednesday evening, on a night that sees many Blues set to represent their respective nations.
Midfielder Osman received his first ever call-up to the Three Lions' squad last week for the friendly against Sweden in Stockholm - and he is joined in the travelling party by club colleagues Phil Jagielka and Leighton Baines.
Elsewhere, Kevin Mirallas is ruled out of Belgium's trip to Romania having withdrawn from the squad with a hamstring injury sustained in Saturday's win against Sunderland.
Mirallas' compatriot Marouane Fellaini is set for action however, with the in-form powerhouse looking to continue his current goalscoring run.
Seamus Coleman's fine performances in the Premier League have earned him another call-up for the Republic of Ireland's friendly against Greece, with fellow defender Shane Duffy on standby for the game in Dublin.
John Heitinga and the Netherlands welcome Germany to Amsterdam in what is poised to be an entertaining 'friendly' contest, while Steven Naismith is in line to face Luxembourg with Scotland.
Saturday's match-winner Nikica Jelavić has been selected to represent Croatia against an XI assembled from the Croatian league in Rijeka.
Tim Howard will don the gloves for the United States as they take on Russia in Krasnodar, with Bryan Oviedo's Costa Rica facing Bolivia in Santa Cruz.
Several young Blues are also set for action, with Apostolos Vellios following up his substitute appearance against Sunderland with action for Greece Under-21s as they entertain Austria.
Matthew Kennedy received a late call-up to the Scotland Under-21 side on Sunday and he heads with the squad to Portugal.
Elsewhere, England Under-19 skipper John Lundstram and striker Chris Long could be in action in Telford where the Young Lions face Finland.
Summer recruit Ben McLaughlin is in the Republic of Ireland Under-19 squad for two games against Switzerland in Monthey, while centre-half Johan Hammar reports to Stockholm for a training camp with Sweden Under-19s.
Keep an eye on evertonfc.com for reports on all of Everton's players on international duty this week.