Leighton Baines and Phil Jagielka head a lengthy list of Everton players away on international duty this week.
The Blues will not be in domestic action until the Premier League campaign resumes with a trip to QPR on Sunday 21 October.
In the meantime, several players have been called up by their countries for the next round of World Cup 2014 qualifiers.
Defensive duo Baines and Jagielka will be looking to keep their places in Roy Hodgson's starting line-up, with the Three Lions set to face San Marino at Wembley on Friday evening before heading to Poland on Tuesday 16 October.
Meanwhile, Kevin Mirallas has been named in Belgium's squad for their qualifiers against Serbia and Scotland, though Steven Naismith misses out for the latter as he serves a two-match international ban. Marouane Fellaini is injured.
Also in Group A, Nikica Jelavic and Croatia take on Macedonia and Wales, while John Heitinga and the Netherlands will be tackling Andorra and Romania in Group D.
Seamus Coleman is in the Republic of Ireland party who face a tricky looking match-up with Germany in Dublin, before also going head-to-head with the minnows of the Faroe Islands.
On the other side of the Atlantic, Tim Howard will be donning the gloves for the United States in their regional qualifiers against the twin-island nation of Antigua and Barbuda before welcoming Guatemala to Kansas City.
Elsewhere in the CONCACAF region, summer signing Bryan Oviedo will be with Costa Rica for their games against El Salvador and Guyana.
At Under-21 level, there is involvement for Greek striker Apostolos Vellios and Portuguese midfielder Francisco Junior.
And Matthew Kennedy, Gethin Jones, Ben McLaughlin and Johan Hammar are in line to feature for Scotland, Wales, Republic of Ireland and Sweden respectively as the Under-19 European Championship qualification stages get underway.
Below is a full list of international fixtures. Keep an eye on evertonfc.com over the next week for more news and updates on Everton players in action.
TUESDAY 9 OCTOBER
Scotland U19s v Armenia U19s
WEDNESDAY 10 OCTOBER
Sweden U19s v Wales U19s
THURSDAY 11 OCTOBER
Scotland U19s v Romania U19s
Luxembourg U19s v Republic of Ireland U19s
FRIDAY 12 OCTOBER
England v San Marino
Serbia v Belgium
Republic of Ireland v Germany
Netherlands v Andorra
Antigua and Barbuda v USA
Macedonia v Croatia
El Salvador v Costa Rica
Greece U21s v Belgium U21s
Sweden U19s v Russia U19s
Slovenia U19s v Wales U19s
SATURDAY 13 OCTOBER
Republic of Ireland U19s v Macedonia U19s
SUNDAY 14 OCTOBER
Scotland U19s v Switzerland U19s
MONDAY 15 OCTOBER
Portugal U21s v Ukraine U21s
Russia U19s v Wales U19s
Slovenia U19s v Sweden U19s
TUESDAY 16 OCTOBER
Poland v England
Belgium v Scotland
Faroe Islands v Republic of Ireland
Romania v Netherlands
Costa Rica v Guyana
Croatia v Wales
USA v Guatemala
Republic of Ireland U19s v Germany U19s