David Moyes is tasked with masterminding the slaying of the wounded animal this weekend.
Manchester United were thrashed 6-1 at home by Manchester City at the weekend and their next league encounter is at Goodison Park on Saturday.
Taking on the Premier League's bigger clubs has become something of a talking point with sides adopting various tactics to counter the wealth of footballing talent the likes of United, City and Chelsea have acquired.
Everton man-marked dangerman David Silva against City recently and employed a high-energy pressing style against Chelsea in Wednesday's Carling Cup clash.
Moyes' approach against the champions is, of course, yet to be revealed. But he has plenty to consider bearing in mind their last league outing.
"You would normally think great - they can't be coming with great confidence and think they have got to be damaged by it but you are talking about Manchester United, and Sir Alex Ferguson," he said.
"We understand totally that they will be desperate to get back to winning ways but we have to try and do our bit to make sure that doesn't happen.
"We had a really good game against them last year and it ended up 3-3, we've tried to keep up with the Joneses as much as we can and we'll try and do it as much as we can to them."
Keeping up with the teams at the very top of the footballing ladder is becoming a global issue and Moyes cited Barcelona's ongoing battle with Real Madrid as an example.
"A lot of the teams are finding it harder," explained Moyes. "There were a lot of games between Barcelona and Real Madrid (in the last 12 months) and everyone was watching to see how Mourinho would try and stop them.
"There were three games and once he did it one way, and then another and he was trying everything in his power to stop them and that is what we have to do with Chelsea, Manchester City and Manchester United because they are a level above us.
"Your job is to try and win but you also have to make it as difficult as you can for them."
An example of Moyes adapting this approach when facing the top sides was provided by the trip to Manchester City last month.
The Blues boss explained: "We played Man City and we decided to man mark David Silva and I remember getting a lot of criticism after the game, with people saying I was being negative.
"But I'd watched them the week before score four and I think it was five the week before that against Tottenham and I felt Silva at the time was by the far the main player.
"I don't think I've ever done that once in my managerial career.
"But at the time I thought the way David Silva was we had to do it and we did a really good job on him for 70 minutes and it took a deflected goal and we eventually lose 2-0 but that's what you have to do as a manager.
"We came very close on that day but we got criticised for not playing two strikers, but you can see what they are doing to some of the good teams."
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