Everton's Carling Cup clash with Chelsea has been confirmed for Wednesday, October 26 (8pm).
The two sides were paired in the fourth round when the draw was made on Saturday lunchtime.
The match, which takes place at Goodison Park, will not be shown live on television.
Everton progressed to this stage with home wins over Sheffield United and West Bromwich Albion.
Chelsea have only played one tie so far, defeating West London rivals Fulham on penalties.
The last time the teams met in this competition was over a two-legged semi-final which Chelsea won in January 2008.
More recently, Everton won an FA Cup tie at Stamford Bridge last season, coming through on penalties after Leighton Baines' dramatic free kick equaliser in the last minute of normal time.
Ticketing information follows.