Iain Turner, Hope Akpan and Kieran Agard have been released.
All three players were out of contract at the end of the 2010/11 season and will now pursue their careers away from Goodison Park.
Goalkeeper Turner, 27, finished the campaign on loan at Preston North End having been with Everton for eight years following a move from Stirling Albion in 2003.
His Blues career was punctuated by numerous loan spells away from the Club and in all he made six appearances for the first team since a senior debut against Chelsea in the FA Cup in February 2006.
Akpan, 19, and Agard, 21, both spent time in the Everton Academy before graduating to the professional ranks. Although both were regular players for the Club’s reserve team, neither managed to make the step up.
Midfielder Akpan, whose solitary senior appearance came in a Europa League tie with Bate Borisov in December 2009, spent time on loan at Hull City earlier this season.
Agard, a pacy striker who also featured against Borisov, tasted Premier League action for the Blues as a substitute against Chelsea and leaves the Club with a total of six senior appearances to his name.
The Blues announced earlier this week that youngsters Aristote Nsiala and James Wallace had penned fresh one-year deals.