David Moyes has revealed a youthful starting eleven to face Borisov, more than 24 hours before kick off at Goodison.
In total, five players make full debuts, as Carlo Nash gets his first senior start since join the Blues in the summer of 2008 replacing Tim Howard.
Shane Duffy, Kieran Agard, Adam Forshaw and Jake Bidwell also make the starting line up for the first time.
The Everton manager has made nine changes from the side that drew 3-3 with Chelsea on Saturday.
But Moyes is keen to stress he is still taking the Europa League seriously.
"I have a lot of respect for the competition but obviously I have changed the team for the Borisov match," explained the manager to evertonfc.com.
"It was a game we had to win then we would obviously play a different line up but we have already qualified for the final 32 and we can't get any higher in the group.
"We have a very busy Christmas coming up and I still don't have many available to me so I have to preserve my players."
Everton starting XI to face BATE Borisov: Nash, Coleman, Duffy, Hibbert (c), Bidwell, Osman, Forshaw, Baxter, Rodwell, Yakubu, Agard.
Fact file on the rising stars at Everton:
39. Hope Akpan: 14.08.91 (age 18)
Hope is a central midfielder and reserve team regular. Born in Childwall but eligible for Nigeria, he’s a box-to-box type player who loves a tackle and has been on the bench for the first team this season.
33. James McCarten: 08.11.90 (age 19)
Born in Netherton, the central defender is strong in the air – he stands six foot five – and is a reserve team regular. James was academy player of the season last season and is dangerous from set pieces – either taking them or getting on the end of them.
37. Jose Baxter: 07.02.92 (age 17)
Bootle born Jose is the club’s youngest ever player after making his debut at the start of the 2008/09 season. An attacking midfielder he has been on the fringes of the first team ever since and has made several substitute appearances this season.
29. Adam Forshaw: 08.10.91 (age 18)
Liverpool born Adam has made himself a reserve team regular this season after a long-term injury. He is most at home on the right-hand side of midfield and is capable of producing excellent delivery from open play and set pieces.
43. Shkodran Mustafi: 17.04.92 (age 17)
Shkodran signed from Hamburg in the summer of 2009 and arrived with a strong reputation in Germany. Mainly a central defender he has played at full back for the reserves this season and has made the first team bench on a couple of occasions.
36. Jake Bidwell: 21.03.93 (age 16)
Jake has England under-16 and under-17 honours and is a powerfully-built left-sided player, usually operating at left-back. Forcing his way into the reserve setup. he already has a Goodison Park goal under his belt after scoring in the FA Youth Cup win over Nantwich last season.
32. Luke Garbutt: 21.05.93 (age 16)
Signed from Leeds in the summer for an initial fee of £600,000 (which could raise by £950,000 based on performance), Luke has England Under-16 and 17 honours but has only made a couple of reserve team appearances this term, as well as featuring for Everton’s Under-18s.
34. Shane Duffy: 01.01.92 (age 17)
Tall central defender Shane arrived from Northern Ireland in July 2008 and progressed through the Under-18s to the reserve side. He has been on the fringes of the first team squad this season, making an 80th-minute substitute appearance in Athens. Has played at every age group level for his country and has also been named in the senior squad, without actually appearing.