Everton v Leyton Orient
New signing Kevin Mirallas made his Everton debut at the weekend and could be handed a first run-out at Goodison Park. Defender Tony Hibbert, who missed Saturday's win at Aston Villa, is David Moyes' only injury concern.
Leyton Orient could hand former QPR winger Lee Cook a debut after he signed a five-month deal with the League One outfit. The O's saw their game against Hartlepool United postponed on Saturday and so could have a fresh squad available for the trip to Merseyside.
Everton head into the cup clash in fine form. An emphatic display at Aston Villa followed a convincing victory over Manchester United, meaning the Blues boast maximum points from their opening two Premier League fixtures.
Orient have endured a tough few weeks since their season started with a penalty shootout victory over Championship side Charlton in the first round of this competition. The O's find themselves without a point from their first two games in League One after suffering a 3-1 defeat at Tranmere and a 1-0 loss at home to Stevenage.
1) Steven Pienaar could make his 150th appearance for Everton in all competitions.
2) Excluding neutral venues, Everton have now been drawn at home in a Club record 10 successive cup ties going back to the fourth round FA Cup encounter with Chelsea in 2011.
3) Paul Rideout remains the last Everton player to score a hat-trick in this competition. The striker bagged three against Lincoln City 19 years ago.
For more match stats and facts, check out our ‘Magic Numbers' feature here.
Everton's latest signing Kevin Mirallas on his disallowed debut goal at Aston Villa and his hopes of playing against Orient: "I don't know if it was offside or not, I couldn't tell. It certainly would have been a fantastic debut if it had counted, but I'll be going all out to score on Wednesday now."
Orient goalkeeper and former Everton Academy star Jamie Jones: "I will be emotional when it has sunk in that I'm playing at Goodison Park in front of the Everton fans and against the team I played for for such a long time. It's just going to be an unbelievable experience the moment I walk out of the tunnel. I'm sure there will be thousands of brilliant, loyal supporters there to watch the game."
Everton 4-1 Leyton Orient, 26 January 2002. The two sides met in the fourth round of the FA Cup in the 2001/02 season. Orient's David McGhee started the scoring early on - albeit into his own net. Duncan Ferguson then netted following good work from Paul Gascoigne before Scott Canham gave the visitors hope from close range. Kevin Campbell ensured the Blues would go into the hat for the next round, however, the striker scoring first on the stroke of half time and again with 10 minutes left to play.
Everton 2-2 Leyton Orient, 3 October 1989, League Cup 2nd Rd, 2nd Leg. With Everton leading 2-0 from the first game at Brisbane Road, Goodison Park witnessed an entertaining score draw that would see the hosts progress. Kevin Sheedy followed up his goal in the first leg with another, while Norman Whiteside also netted for the Toffees.
On 29 August 1978, Everton beat Wimbledon 8-0 in the League Cup. Midfielder Martin Dobson helped himself to a hat-trick on the night but still found himself upstaged - Big Bob Latchford got the other five!
In addition to Jamie Jones, striker Michael Symes is another former Everton Academy player who could line up against his old side on Wednesday.
Johnny Carey is the only manager to have been in charge at both clubs, with his spell at Everton (1958-61) preceding his time at Orient (1961-63).
And former Everton forward Kevin Campbell spent a successful spell on loan at Brisbane Road in his early days at Arsenal, netting nine goals in 16 appearances.
Referee: Mr R East
Assistant Referee: Mr M Astley
Assistant Referee: Mr P Hodskinson
Fourth Official: Mr N Greenhalgh
Tickets for Everton's game against Leyton Orient are still available and can be purchased by clicking here, visiting the Park End Box Office or by calling 0871 663 1878.
Supporters have been urged to buy their tickets in plenty of time in order to avoid queues at the Box Office. Click here for more information.
Our official online betting partner Paddy Power are offering a range of odds on Wednesday's game. Here's our pick of the best:
Everton to win 2-0: 11/2
Steven Naismith to score the first goal: 7/2
Darron Gibson to score the last goal: 11/1
Nikica Jelavic to score two or more goals: 11/5
Everton to win the Capital League Cup: 14/1