Everton U21s v Bolton U21s
The duo were named on the bench for the first-team's 3-1 victory over Southampton on Saturday, but did not feature.
Sunday's fixture therefore offered both men the opportunity to gain valuable game time against the Wanderers - as Alan Stubbs' side aim for successive victories.
Elsewhere, Mateusz Taudul keeps his place in goal, behind a back four of Tyias Browning, Ibou Touray, Matthew Pennington and Duffy.
Anton Forrester partners Apostolos Vellios in attack, while there is space on the bench for Conor Grant, Chris Long and George Green, who all competed for the Under-18s on Saturday.
Everton U21s (to face Bolton): Taudul, Browning, Touray, Junior, Pennington, Duffy, Kennedy, Kelly, Vellios, Forrester, Gueye.
Subs: Springthorpe, McAleny, Grant, Long, Green.
Bolton: Lych, Riley, Keilett, Mcquade, Threlkeld, Blakeman, Lester, Kelly, Odelusi, O'Halloran, Wylde.
Subs: Sampson, Fielding, Hampson, McKee, Woodland.