Everton v Manchester United
Everton captain Phil Neville was withdrawn at half time in the Blues' Carling Cup fourth round defeat to Chelsea on Wednesday and is a doubt to face his former club. Tim Cahill is also carrying an injury.
Royston Drenthe's sending off for two bookable offences means he will serve a one match suspension on Saturday.
Manchester United made 11 changes for their midweek cup win over Aldershot from the side that were thrashed 6-1 by neighbours Manchester City last Sunday.
Ashley Young is a doubt for United with a toe injury, but Nemanja Vidic and Tom Cleverley returned in the Carling Cup and could feature at Goodison Park.
Everton won for the first time in four Premier League games at Craven Cottage last week when injury time strikes from Louis Saha and Jack Rodwell sealed a 3-1 win over Fulham.
The Blues saw their four match unbeaten run at Goodison Park on Wednesday when Daniel Sturridge's extra time goal saw them slip to a 2-1 Carling Cup defeat to Chelsea.
The football world was stunned on Sunday when United were hammered 6-1 at home by local rivals Manchester City, it means Sir Alex Ferguson's side have now only won one of their last four Premier League fixtures.
The champion's backline has been a particular cause for concern - they've shipped 12 goals this season and Spurs are the only top six side to have conceded more.
1. In the last two campaigns Everton have scored three goals at Goodison against United, the first time in successive seasons since 1985/86 and 1986/87.
2. Everton have not been scored a league penalty against Manchester United since September 1972, when Joe Royle netted at Goodison.
3. Wayne Rooney has scored twice in 11 fixtures against his former clubs and not since April 2007.
4. Graeme Sharp scored a Club record 12 goals for Everton against Manchester United
5. Everton manager David Moyes has won three of the nineteen games he's taken charge of against Manchester United, and is unbeaten in the last three at Goodison Park.
MANCHESTER UNITED 1-0 EVERTON (Saturday 23 April 2011): The Blues battled bravely for over 80 minutes at Old Trafford in April but a back post header from Javier Hernandez proved decisive as Manchester United closed in on a 19th top flight title.
EVERTON 3-3 MANCHESTER UNITED (Saturday 11 September 2010): Everton incredibly came back from two goals down in injury time to snatch a point when Manchester United last visited Goodison Park. Steven Pienaar had given the Blues the lead before Darren Flether, Nemanja Vidic and Dimitar Berbatov put United on course for what looked like a routine win. But a Tim Cahill header and a Mikel Arteta rescued a quite unlikely draw for David Moyes' side.
As many as four players who have represented both Manchester United and Everton could feature at Goodison Park on Saturday with Blues trio Tim Howard, Phil Neville and Louis Saha and Manchester United striker Wayne Rooney.
Others to have played for both club include Mark Higgins, Peter Beardsley, Norman Whiteside, Mickey Thomas, Jesper Blomqvist and one of the stars of Saturday's matchday programme Andrei Kanchelskis.
It's now two goals in two games for Blues striker Louis Saha after and the Frenchman is available at 8.50 to open the scoring at Goodison Park on Saturday.
There are still a few tickets available for Saturday's lunchtime kick-off against Manchester United. Click here for details or call the box office on 0871 663 1878.