Liverpool v Everton
Liverpool are likely to field third-choice goalkeeper Brad Jones at the national stadium, with Doni joining Pepe Reina on the suspension list following his dismissal against Blackburn on Tuesday.
Manager Kenny Dalglish opted to rest captain Steven Gerrard, Jamie Carragher and Stewart Downing for the game at Ewood Park, while Luis Suarez was an unused substitute. Glen Johnson returned for the 3-2 win having been sidelined since the Reds' last Wembley appearance in February's Carling Cup final.
Midfield duo Charlie Adam and Lucas Leiva are both set to miss out with long-term injuries.
Everton have reported no fresh injury concerns from the Easter Weekend action. Only Jack Rodwell remains unlikely to feature, as the England international continues his recovery from hamstring troubles.
The Blues will definitely be without the cup-tied Steven Pienaar.
Liverpool: WDLLLW. Blackburn (a), won 3-2; Aston Villa (h), drew 1-1; Newcastle (a), lost 2-0; Wigan (h), lost 2-1; QPR (a), lost 3-2; Stoke City (h), FA Cup, won 2-1.
Everton: WDWWWL. Sunderland (h), won 4-0; Norwich (a), drew 2-2; West Brom (h), won 2-0; Sunderland (a), FA Cup, won 2-0; Swansea (a), won 2-0; Arsenal (h), lost 1-0.
ROAD TO WEMBLEY
Liverpool began their FA Cup campaign with a 5-1 home win over League One side Oldham. Robbie Simpson gave the visitors a shock lead, but Craig Bellamy, Gerrard, Jonjo Shelvey, Downing and Andy Carroll all netted to turn the tie around.
Everton kicked off their third round clash the next day, hosting non-league outfit Tamworth. An early goal from John Heitinga and a penalty from Leighton Baines gave David Moyes' side a 2-0 win and a place in the fourth round.
They faced Premier League opposition in the next round in a memorable Friday night clash at Goodison. Fulham took the lead from the spot through Danny Murphy, before Denis Stracqualursi and Marouane Fellaini each headed home from Landon Donovan crosses to cap a fine 2-1 victory.
The Reds were drawn against Manchester United at home the following afternoon, an 88th-minute strike from Dirk Kuyt sealing a 2-1 win following goals from Daniel Agger and Ji-Sung Park.
Blackpool were the next visitors to the Blue half of Merseyside in round five. Royston Drenthe's powerful breakthrough after just 49 seconds was followed by Stracqualursi's close-range finish just six minutes later as the hosts completed a 2-0 win.
Liverpool came up against Brighton meanwhile, with the Championship outfit scoring four times and still losing. The scoreline was actually 6-1 to the hosts, but a trio of own goals added to strikes from Martin Skrtel, Carroll and Suarez to help the Reds into the last eight of the competition.
Everton shared a 1-1 draw with Sunderland in the quarter-final at Goodison Park after Tim Cahill's header cancelled out Phil Bardsley's drive to force a replay at the Stadium of Light.
There, Nikica Jelavic spearheaded an attacking Toffees side, scoring the first and forcing a David Vaughan own goal for the second to bring about an impressive 2-0 win.
By that point, Liverpool had already booked their place at Wembley, a 2-1 triumph over Stoke coming courtesy of goals from Suarez and Downing.
1) Saturday's meeting will be the 218th fixture between the sides in all competitions.
2) The 4-0 victory over Sunderland was David Moyes' 250th league win as a manager.
3) John Heitinga could make his 100th appearance for Everton.
4) The Toffees' next derby goal will be their 250th in all competitions.
5) No tie between Everton and Liverpool has ever gone to penalties.
Everton manager David Moyes: “It's magical to go to Wembley again. To be the manager of Everton, take them back to Wembley and to get the supporters there, I think that's special.”
Injured Liverpool midfielder Lucas Leiva: "I think it's a fantastic game for both sides, the first semi-final at Wembley. It will be a special day for the clubs and the city. We're all looking forward to it. Hopefully we can play well and beat them for the third time this season."
Everton skipper Phil Neville: "I think games between Everton and Liverpool are magical anyway but being at Wembley - I was a kid growing up for the '86 final and the '89 final and you just remember them as being magical occasions for the city and you'd hope that one day you'd play in a game of that magnitude. Saturday is that."
Reds goalkeeper Brad Jones: “It’s going to be a big occasion against Everton. I have to make sure I do the right things and it’s going to be an extra special day."
Blues full-back Leighton Baines: "It's massive for the city and, being a local lad, I know what it means to everyone. I've got family and friends that are Red and Blue, so it'll be an exciting week building up to the game."
Liverpool defender Jose Enrique: "In the league, we know we have to try to finish as high as possible, but the truth is the league isn’t as important as the Cup now. In the league we aren’t playing for anything. The semi-final is very important. It will be amazing – two teams playing at 200 per cent. It will be a special game for everyone and we have to win."
March 13, 2012. Liverpool 3-0 Everton. Steven Gerrard spoiled the anniversary celebrations on the eve of David Moyes completing 10 years in charge of the Blues. A hat-trick from the midfielder - the third coming in injury time – earning all three points for the hosts.
February 20, 1991. Everton 4-4 Liverpool. Goodison Park witnessed an absolute cracker of an FA Cup meeting as the two rivals contested a fifth round replay. With the original tie at Anfield ending goalless, the goals flew in on the opposite side of Stanley Park. Peter Beardsley struck first, with Graeme Sharp levelling moments after half time. It was Beardsley who struck again for the Reds with 20 minutes to go, but Sharp made it all square almost immediately. Ian Rush replied just as quickly for the visitors, only for sub Tony Cottee to net an 89th-minute equaliser.
The game headed into extra time and John Barnes' long-range curler on 102 minutes looked to have won it for Liverpool. But Cottee popped up for a second time and capped a memorable night with just six minutes left on the clock.
Due to the rules of the competition then, a second replay was arranged, the Blues finally prevailing a week later with defender Dave Watson claiming the only goal.
A fierce rivalry hasn't stopped a select group of players appearing for both Everton and Liverpool. Here's a full XI of those that have worn both Blue and Red on Merseyside.
In goal, former Dutch international Sander Westerveld makes the grade after his loan spell at Goodison in 2006.
Heroic Toffee defender Dave Watson started his career with Liverpool, playing for their reserve side before a switch to Norwich City.
He is joined at the back by the late Gary Ablett, David Burrows and Abel Xavier.
The midfield consists of current Hull City manager Nick Barmby and Blues Academy boss Kevin Sheedy on the wings. Don Hutchison and Steve McMahon team up in the centre of the park.
Dave Hickson and Peter Beardsley lead the line in attack.
Everton's allocation for the game at Wembley has sold out. Free live updates and radio commentary will be available here on evertonfc.com.