One to watch: Ruben Neves
Richarlison and Lucas Digne are in line to make their competitive Everton debuts as the Blues travel to Wolverhampton Wanderers for their opening game of the 2018-19 Premier League campaign.
Deadline day signings Bernard, Yerry Mina and Andre Gomes will not be available for the Molineux clash, however.
A host of Wolves’ new arrivals could also make their bows. Rui Patricio, Joao Moutinho, Raul Jimenez, Leander Dendoncker and Jonny Castro are all possible starters for Nuno Espirito Santo’s side.
Club-record signing Adama Traore is doubtful, however. The winger is recovering from a shoulder injury.
Key stats, facts and milestones ahead of Saturday's game at Molineux.
Everton have lost just one of their eight Premier League encounters with Wolves (won three, drew four, lost one).
The Blues have not lost their first game of the season since August 2011 (won two, drew four).
Everton have lost just three of their opening away Premier League games of the season since 2001 (won 10, drew four, lost three).
The two managers faced each other four times in the Portuguese Primeira Liga from 2012-14, when Silva was Estoril boss and Nuno was in charge at Rio Ave. All four games were won by the away team.
Phil Jagielka needs one more start to reach 300 for the Toffees in the Premier League – only Leighton Baines (318) has made more as an outfield player.
Michael Keane requires one more appearance to reach 200 career club games.
After joining Wolves from Porto last summer for a then club-record fee of around £16million, Neves went on to more than justify his price tag as the Midlands side romped to the Championship title.
A composed, skilful midfielder with penchant for the spectacular – all six of his goals last season were strikes from outside the box – Neves was at the heartbeat of Wolves’ promotion campaign.
Still just 21, he has been capped five times for Portugal. Last month he signed a new contract for Wolves that will keep him at Molineux until 2023.
Man in the Middle: Craig Pawson
Premier League games refereed in 2017/18: 24
Yellow cards issued: 81
Red cards issued: 4