Ronald Koeman admits he is unsure whether James McCarthy will play again this season, as the midfielder continues to struggle with a hamstring injury.
Enner Valencia is ineligible under the terms of his loan move from West Ham United, but Koeman revealed in his pre-match press conference that he has no further absentees.
Jonjoe Kenny is set for a place on the bench at the London Stadium despite his likely inclusion in the Under-23s’ match with Chelsea on Friday night.
The Hammers are boosted by the return of New Zealand international Winston Reid. However, Michail Antonio continues to be sidelined, alongside long-term absentees Pedro Obiang, Angelo Ogbonna and Gokhan Tore.
Aaron Cresswell and Andy Carroll are both doubts, and captain Mark Noble and defender Sam Byram are suspended.
The Blues have plenty of momentum going into the last five games of the season. They have bounced back from the defeat at Liverpool at the beginning of April by going unbeaten in their past three games.
The point and resolute display at Manchester United was followed up by successive wins over reigning Premier League champions Leicester City and then Burnley at Goodison Park.
Phil Jagielka and Romelu Lukaku contributed five of the seven goals Everton scored in those respective 4-2 and 3-1 successes.
West Ham, meanwhile, are closing in on Premier League safety, with 37 points so far.
The Hammers have had a mixed bag of results of late – losing to both Arsenal and Hull City, before defeating Swansea City and drawing at Sunderland.
Everton 2-0 West Ham United
The Blues needed a win after five games without one back in October, but earned all three points when the Hammers visited Goodison Park.
West Ham’s nemesis, Romelu Lukaku, netted his seventh goal against them when he nodded home Yannick Bolasie’s sliding cross.
Lukaku also had a hand in the second. After Ross Barkley won the ball in midfield, he sprayed a pass out wide to the right for the striker. He bided his time before clipping over a ball that Barkley half-volleyed into the back of the net to secure the victory.
Greater emphasis has been placed on the playmaking ability of Argentinian schemer Lanzini after the departure of Dimitri Payet in January.
Yet the former Al Jazira midfielder has stepped up to the plate, bettering his figures of last season.
In 2015/16, while on loan from the United Arab Emirates side, Lanzini racked up six goals and two assists, prompting the Hammers to make the move permanent.
But in the current campaign, Lanzini boasts seven goals and a pair of assists, with a better shooting accuracy (29 per cent, up from 23 per cent). With one of his goals coming from a free-kick and two from the penalty spot, he is a danger from set-pieces as well.
MAN IN THE MIDDLE
Saturday will be game number 31 for Wiltshire’s Roger East. The experienced referee has overseen games from League Two right the way through to the Premier League in that sequence, but this will be his first Everton fixture of the season.
His last Blues game was the 3-1 win at Aston Villa back in March 2016.
During the current campaign, he has issued 129 yellow cards and five reds so far.
As always, there will be free live audio commentary of Saturday’s contest here on evertonfc.com.
Click here to listen to broadcast duo Graham Stuart and Darren Griffiths’s coverage of the action on matchday.
Get involved in the broadcast on Saturday by tweeting in your shout-out requests using #EFCLive.
In addition to our live commentary, look out for the brand new live blog which will bring you updates, imagery, video and team news from Stamford Bridge. Head to the match centre, the official App or the evertonfc.com homepage on matchday to find it.