Everton's Dresden Cup participation ended in defeat on penalties after a 1-1 draw in normal time with Real Betis.
The Blues took an early lead when defender Aissa Mandi put through his own net, only for German Pezzella to scramble a leveller before the break.
No further goals meant the contest went immediately to a shootout, with the Spaniards prevailing 4-3 after goalkeeper Adan made amends for an earlier mistake with saves from Kieran Dowell and Conor Grant.
Romelu Lukaku, Gareth Barry and Arouna Kone all made their first appearances of pre-season as Ronald Koeman opted to make 11 changes and rest those who had started against Dynamo Dresden less than 24 hours earlier.
After a quiet opening, Everton were gifted the lead on 13 minutes thanks to some calamitous Betis defending.
Racing out to claim Tom Cleverley's corner, goalkeeper Adan got nowhere near it and could only watch on as the ball flicked off Mandi and into the unguarded net. With each goal counting as a point, it was an easy one towards Everton's overall Dresden Cup tally.
The lead, however, would only last 10 minutes as the La Liga outfit quickly struck back.
From a free-kick, Joel Robles pushed Felipe Gutierrez's header on to the post but the ball cannoned back across goal, allowing Pezzella to stab home from point-blank range.
Despite the blow, Everton continued to keep possession better than their hosts and, as with the previous night's encounter with Dynamo, created a greater number of sights on goal.
However, in the Dresden sunshine, the Blues couldn't find a way through and on the hour-mark Koeman called for three of his youngsters.
Replacing Lukaku, Barry and James McCarthy, the Dutchman sent on Dowell, Tom Davies and Grant - and it so nearly paid off.
A move involving all three ended in the ball finding its way out to Grant down the Everton left with 70 minutes on the clock but his arrowed centre across the box narrowly evaded the lurking Kone.
Grant then went close himself, the midfielder forcing Adan into a full stretch save with a low drive from 20 yards before firing another chance into the keeper's side-netting.
A sour note for the Blues saw another youngster Matthew Pennington limp off injured with 11 minutes remaining as John Stones came on as his replacement.
Yet it was another defender, Bryan Oviedo, who had to come to the rescue late on to step in and deny substitute Alex Alegria as he menacingly turned on to his left foot on the edge of the six-yard box.
The intervention ensured the penalty shootout, though there was a comedy moment at the final whistle when the Costa Rican threw his shirt into the Everton end of the DDV Stadion seemingly unaware of the need for a decider.
Koeman's men will now have to await the result of the tournament's final game between Dynamo Dresden and Werder Bremen later on Saturday to establish their final Dresden Cup standing.
Everton return to action on Wednesday when they head down to Old Trafford to take on Manchester United in a testimonial for Blues Academy graduate Wayne Rooney.
How The Penalties Unfolded