Everton left North London with a hard-earned point after a 0-0 draw at Spurs.
But there was serious collateral damage at White Hart Lane when Tom Cleverley was stretchered off with what looked to be a serious injury.
Tin Howard produced a number of excellent first half saves - but the Blues had chances of their own after half-time as honours remained even.
The Everton fans were in typically noisy and boisterous mood early on, backing their team as both sides attempted to wrestle control of the game.
It was evenly balanced in the opening exchanges but the home side gradually gained more control of proceedings.
Harry Kane dragged a tame effort wide after Eric Dier had robbed Ross Barkley in midfield.
Then, 15 minutes in, Nacer Chadli teased Seamus Coleman down the Spurs left and then teed up Nabil Bentaleb to shoot low and a yard or so past Tim Howard’s left-hand post.
Cleverley had Everton’s best opening moments later when he dispossessed Kyle Walker, cut infield and unleashed a powerful drive which Hugo Lloris turned over at full stretch.
Then Tottenham took real control and produced a series of attempts on goal which required Tim Howard to produce a sequence of superb saves.
First, on 23 minutes, he denied Kane one-on-one after the forward raced on to Ryan Mason’s through pass.
Next the keeper was out smartly to deny Mason, who this time sprinted on to Chadli’s clever pass.
Soon after, Bentaleb took aim from range but again Howard was equal to his low drive.
The glovesman completed his first half repertoire by tipping Toby Alderweireld’s powerful header from a corner over the crossbar.
By way of reply, Barkley managed a tame snapshot that was easy for Lloris but then Cleverley’s moment of despair hit.
There was concern for the busy summer arrival after he injured his right leg in an awkward collision with Dier as the pair hurtled down the Everton left.
The England midfielder instantly signalled his discomfort and the sight of him leaving the pitch on a stretcher was a depressing one for all Evertonians. Kevin Mirallas replaced him.
Chadli screwed a drive wide at the start of the second half as Spurs picked up where they’d left off.
Dembele became the game’s second player to leave on a stretcher but it didn’t prevent the home side again testing Howard shortly after as Mason again brought the best from the American.
As the hour mark approached Everton enjoyed a better spell and, perhaps rattled, three Spurs midfielders quickly went into the book.
The hosts remained dangerous though and Chadli skied a decent opening with 25 minutes left.
Steven Naismith was thrust into the fray in place of Lukaku but Spurs continued to make chances and Jan Vertonghen was next to go close, firing over after a marauding run from the back.
Lukaku’s exit meant Arouna Kone moved to a central role and his header from Oviedo’s cross was a whisker away.
The Toffees continued to probe the goal in front of their travelling fans and Mirallas struck a free-kick a couple of yards over with 10 minutes left.
But it finished goalless in North London as both sides were forced to share the spoils.