Steven Naismith proved Chelsea's tormentor once again as the Scot stepped off the bench to net a perfect hat-trick and consigned Jose Mourinho's champions to a comprehensive defeat at Goodison Park.
Almost two years to the day, Naismith had grabbed the only goal against the Londoners on the same ground to give Roberto Martinez his first win as Everton boss.
Here, the former Rangers man came on in place of the injury-stricken Muhamed Besic with just nine minutes played and grabbed a quick-fire double - his fourth and fifth goals for Everton in all games against Chelsea - before Nemanja Matic pulled one back with a thunderous 36th-minute strike.
Yet, Naismith wasn't done there and capped off a magical afternoon when he somehow angled the ball under goalkeeper Asmir Begovic to wrap up the points with seven minutes remaining and complete what was the first league treble by an Everton player since Louis Saha hit four against Blackpool in February 2011.
A positive afternoon for the Toffees also saw Aaron Lennon make his second debut as a second-half substitute and defender Ramiro Funes Mori follow the winger off the bench to sample a first taste of life in royal blue.
Martinez made two enforced changes from the goalless draw at Tottenham Hotspur, replacing the injured pairing of Bryan Oviedo and Tom Cleverley with the fit-again Brendan Galloway and Besic.
However, Besic - making his first Premier League appearance of the campaign after sitting out much of the action since July with a hamstring injury - was soon clutching the back of his leg and signalling to the bench.
Unfortunate on the Bosnian, it proved the key moment in the game for the Toffees.
Within seconds of coming on, Naismith provided Chelsea's rearguard with a barely-required reminder of his menace, narrowly failing to get on the end of a Seamus Coleman cross that was whipped towards the back post.
When the ball came in from the opposite flank five minutes later, he did get his head on it. And some.
Prodding a pass out to Galloway down the left, Naismith continued his run into the box, and when the 19-year-old guided a pinpoint delivery into the heart of it, there was the Scot to meet it with impeccable precision and rocket a header high to Begovic's left.
But for Chelsea's Bosnian stopper, the hosts might have made it two soon after, Arouna Kone spurned by a fine Begovic reaction stop having stretched his neck muscles to get power on a dinked tee up from Coleman.
Begovic could only tip the Ivorian's effort out for a corner though, and when a short routine eventually resulted in the ball being fed into the path of James McCarthy 30-yards out, the former Stoke keeper again had to be on his toes to keep it at one.
It wasn't that way for long.
Indeed, just 13 minutes after making his entrance, Naismith was wheeling away to celebrate his second of the afternoon and another clinical finish.
Romelu Lukaku fed the ball to Barkley, who in turn nudged it forward for the Scot 20 yards from goal. Two touches later and his left-footed shot was skipping across the turf, destined for Begovic's bottom left corner.
Stunned, Chelsea did manage to half the deficit before the break. And, in keeping with the contest, it was a belter.
When Matic picked up a pass from John Obi Mikel just past the centre circle, there appeared to be little danger. Yet, the Serbia international - scorer of just four goals in almost 200 career appearances - let fly, rendering Tim Howard a mere bystander as his shot tore into the top corner of the Gwladys Street net.
But, with Chelsea pushing for an equaliser as the seconds ticked by, Barkley found Naismith again and the man of the moment squeezed the ball home with his right boot to seal his matchball. In doing so, he not only ended Everton's four-year wait for a Premier League hat-trick, he became the first Blue to get one against Chelsea since Dixie Dean hit five past the Stamford Bridge outfit in November 1931.
Before that, Lennon was welcomed back to a standing ovation when he replaced Kone on 71 minutes, while Mori gave the Goodison faithful a first glimpse of his talents, demonstrating his recent assertion that he likes a header with a number of late aerial clearances.
Martinez said afterwards that being able to show off the strength and depth of his squad was one of the most pleasing aspects of a "complete" performance.
Two years ago, Naismith's intervention against Chelsea sparked an eventual record Premier League points tally of 72 for Everton. The 38,000 Toffees joyously pouring away from L4 on Saturday would certainly take a similar tale this time around.